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‘Autism gene search turns up hope for treatment’

July 11th, 2008

From Reuters, the Washington Post, Time magazine, ABC News and elsewhere:

A study published in the journal Science says researchers have identified at least six new genes that appear to underlie autism, and “said they suggest it may be possible to treat it sometimes.”

The study suggests that some of the genes can be turned on or off by mental activity.

The fact that three of the half-dozen genes identified in the new report are regulated by “neuronal activity” — feeling, thinking, doing — suggests in theory that changing the experiences of autistic children could change the course of the disease.

“The genes implicated in our study are ones that interact with the environment and are involved in how the brain converts what it sees from the environment,” said Christopher A. Walsh, a neurologist and chief of genetics at Children’s Hospital in Boston who headed the team. “If we can activate those genes by other mechanisms, we might be able to help the kids.”

The study is based on scans of 104 families in the United States, Pakistan, Turkey, Jordan, Saudi Arabia and Kuwait in which autism is unusually common. In 88, the parents were cousins. The average family had two autistic children. One Kuwaiti and one Pakistani family, however, each had four.

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More than 50 million people in the United States have disabilities, a number that is growing rapidly as the population ages. Experts say disability will soon affect the lives of most Americans. This blog attempts to explore what we know about disability, and to chronicle the efforts of people who are seeking new ways to address familiar challenges.

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